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| 1852 |
| | | Harriet Beecher Stowe publishes a massively successful antislavery novel, Uncle Tom's Cabin, that sells 300,000 copies in its first year | |
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| 1852 |
| | | US entrepreneur Cornelius Vanderbilt conveys passengers across the American continent through Nicaragua by steamship and horse and carriage | |
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| 1852 |
| | | In an Argentinian civil war, Urquiza defeats the dictator Rosas and is subsequently elected president (in 1854) | |
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| 1852 |
| | | Russia insists that her exclusive rights over the Holy Places are enshrined in the treaty of Kuchuk Kainarji | |
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| 1852 |
| | | Democratic candidate Franklin Pierce wins the US presidential election, defeating his Whig opponent Winfield Scott | |
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| 1852 |
| | | Louis Napoleon, asking the French people to approve his elevation to emperor as Napoleon III, receives a resounding yes in the plebiscite | |
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| 1852 |
| | | Lord Aberdeen, leader of the 'Peelite' minority of the Conservative party, forms a new coalition government with the Liberals | |
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| 1852 |
| | | London physician Peter Mark Roget publishes his dictionary of synonyms, the Thesaurus of English Words and Phrases | |
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| 1853 |
| | | Giuseppe Verdi's opera Il Trovatore is a success at its premiere in Rome | |
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| 1853 |
| | | David Livingstone makes a heroic six-month journey from the Zambezi river to the west coast of Africa | |
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